NMN Supplementation and Cellular Energy
As we age, NAD+ levels naturally decline, potentially impacting how our cells generate vital energy.
This study explored how oral NMN supplementation affects blood NAD+ concentrations in healthy middle-aged adults. The results suggest a significant increase in markers of cellular health over a 60-day period.
What was studied
Maintaining cellular energy is a cornerstone of the Welcuren philosophy. This multicentre, randomised, double-blind, placebo-controlled clinical trial investigated the safety and efficacy of Nicotinamide Mononucleotide (NMN) in 80 healthy middle-aged adults. Participants were divided into groups receiving different daily amounts of NMN or a placebo for 60 days to determine how effectively the body converts these precursors into active NAD+.
What it found
The study reported that NMN supplementation was well-tolerated and significantly increased NAD+ concentrations in the blood compared to the placebo group. Those taking the highest amounts showed the most substantial increases. Furthermore, participants in the NMN groups demonstrated improved walking distance in a six-minute endurance test and reported better general health scores. This suggests that supporting our NAD+ levels may play a role in maintaining physical vitality as we grow older. If you are considering support for your cellular health, your clinician can advise whether it's suitable.
What it doesn't tell us
While the results are promising for mid-life vitality, the study was limited to a 60-day window. We do not yet have long-term data over several decades to see how these changes influence overall lifespan. Additionally, because the participants were healthy, the study does not address how those with specific pre-existing metabolic conditions might respond. Further large-scale trials are needed to standardise long-term wellness protocols.
- Yi et al., 2023, GeroScience — The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. View paper
Was this helpful?
Questions about this?
Our assistant can explain it simply, or a clinician can advise you personally.
Educational content, not medical advice. Treatments are only prescribed after an online consultation, at a clinician's discretion.
Next best read
Picked from what you've been reading
The 3pm energy dip, explained
Understanding why your focus fades mid-afternoon involves looking deep within your cellular power plants.
Mastering your first hour of light
The secret to a better night's sleep actually begins the moment you open your eyes in the morning.
Why your 'multiple tabs' habit is draining you
Why context-switching is the hidden cause of your mental exhaustion and how to restore neural balance.